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Formulation And Stability Evaluation Of An Optimum Opical Preparation Using Hippophae Rhamnoidesl. Oil For The Treatment of Psoriasis

by Hina Hussain | Muhammad Irfan Masood | Dr. Farzana Chowdhary | Dr. Muhammad.

Material type: book Book; Format: print Publisher: 2012Dissertation note: Multiple emulsion is a triphasic system in which the two miscible phases are separated from each other by an inner immiscible phase. In w/o/w multiple emulsion the two queous phases are separated by oily layer. Formulation and stabilization of multiple emulsions from natural oil is the difficult task due to the complex nature of the oil and poor interaction with emulsifiers. Hippophae rhamnoide L. oil, a natural oil, obtained from barries of plant belong to family Elaeagniaceae naturally found in northern areas of Pakistan is effective for healing of skin wounds, Eczema and Psoriasis. In the present study two multiple emulsions were prepared multiple emulsion base 'B' (containing Magnesium sulfate as marker substance) and multiple emulsion formulation 'F' Containing zinc sulfate as (active ingredient). Both preparations contained Hipophae rhamnoides L. oil. Both multiple emulsions were prepared using Two-step method and its stability was evaluated by observing changes in organoleptic parameters, pH, globule size, electrical conductivity and viscosity in samples kept at 4Co ,25Co, 40Co ,40Co+75% RH at various time intervals (Ohr.24hrs,48hrs,72hrs,lstweek, 2ndweek,3rd week, 4th week) for period of 28 days. Data was analyzed using ANOV A-Two ways and LSD design to see variations in parameters at time and temperature levels in each formulation kept at different storage conditions and unpaired student T-test to compare results of stability parameters of Formulation B with Formulation F . Both the multiple emulsions B' and 'F' showed phase inversion at 4°C after 24hrs of storage were excluded from further evaluation. Change in color was observed in all the samples except sample at 2SoC. Sample of multiple emulsion base 'B' kept at 40Co + 7S% RH showed liquefaction after 72 hours. Multiple emulsion formulation 'F' at 40Co and 40Co + 7S% RH showed a significant change in liquefaction and phase separation. The average globule size of multiple emulsion base 'B' (TZurn) is larger than the multiple emulsion formulation 'F' which decreased more significantly in the samples of multiple emulsion base 'B' than samples of'F'. Similarly the pH of the multiple emulsion 'B' (S.l) is more than 'F' (4.2) but in both multiple emulsions kept at different temperatures increased significantly. The increase in electrical conductivity and decrease in viscosity of both multiple emulsions 'B' and 'F' was rather more at 40°C and 40°C+ 7S%RH temperatures while this change was comparatively more in multiple emulsion 'F'. So multiple emulsion 'B' and 'F' at 25°C were stable with respect to organoleptic parameters (except liquefaction), centrifugation, globule size, pH, electrical conductivity and viscosity change than at other temperatures (40°C and 40°C + 7S% RH). Multiple emulsion 'F' is rather more stable at 25°C than 'B' as no liquefaction occurred during the whole stability period in 'F'. For multiple emulsions from Hippophae rhamnoide L. oil refrigeration and high temperature storage condition is fatal for the stability and for relatively high shelf life formulation must be stored at room temperature. Multiple emulsion has advantages over simple emulsion as the droplets may act as reservoir for entrapping the drug molecules to release them slowly to the outer continuous phase so the advantages of multiple emulsion are i) the protection of material entrapped in the internal phase ii) more than one incompatible components can be formulated in a single preparation. None of the multiple emulsions for dermal applications has yet been available in Pakistani market so keeping in view the advantages of multiple emulsion and the Hippophae rhamnoides L. oil prospective researchers hereby suggested to manufacture such a stable formulation which can effectively be marketed in this region. Availability: Items available for loan: UVAS Library [Call number: 1403,T] (1).

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Formulation Of Honey And Propolis Based Microemulsion Gel And Its Effects On Burns

by Shazia Ishaque | Dr. Sonia Khiljee | Dr. Muhammad | Malik Allah Bukhsh Awan.

Material type: book Book; Format: print Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1726,T] (1).

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Formulation Of Microemulsion Containing Nigella Sativa Honey And Propolis, And Evaluation Its Burns

by Faizah Sulaiman | Dr. Sonia Khiljee | Dr. Muhammad | Muhammad Irfan Masood.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1738,T] (1).

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Invitro Evaluation Of Microemulsion Containing Extract Of Lawsonia Inermis

by Aysha Aslam | Dr. Sonia Khiljee | Allah Buksh Awan | Dr. Muhammad.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2013Dissertation note: The objective of the present study is to develop an optimum microemulsion formulation of Lawsone, for transdermal delivery. This study also investigated the effects of surfactants and cosurfactants and oils on the percutaneous delivery of Lawsone microemulsion. Oleic acid was selected as the oil phase, Tween 80 as surfactant and Ethanol as cosurfactant of the microemulsion due to its good solubilizing capacity for the drug. The microemulsion area was identified by constructing Pseudoternary phase diagrams with different surfactant-cosurfactant mixtures (Smix) and oil. 5% Lawsone microemulsion was prepared. Transdermal permeation of Lawsone microemulsion was determined in vitro using Franz diffusion cell. In vitro permeation profiles showed that incorporation of Lawsone in microemulsion increased the permeation rate as compared to the saturated aqueous solution. The formulation passed thermodynamic stability tests were characterized for viscosity, pH and conductivity. In vitro skin permeation of these formulations was also determined. The optimum microemulsion formulation comprised of 5% Lawsone, 5% Oleic acid, 95% Tween 80 and ethanol (1:1). The formulation was found to be non-irritant to the skin. These results indicate that the type of surfactant and cosurfactant affect both the phase behaviour and transdermal drug delivery ability of microemulsion; and the studied microemulsions are potential vehicles for improved transdermal delivery of Lawsone. Keywords: Transdermal microemulsion, Lawsone, Surfactants, Cosurfactants. Availability: Items available for loan: UVAS Library [Call number: 1773,T] (1).

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Evaluation And Monitoring Of Therapeutic Outcomes In Chronic Hepatitis C Patients With Interferon And Ribavirin

by Ghazala rafique | Malik allah bukhsh | Dr. Sonia khilji | Prof. Dr. Muhammad.

Material type: book Book; Format: print Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2043,T] (1).

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